Ganoderma
Effect Of Cigarette Smoking On Blood Lipid Peroxides And Antioxidants
150 Faculty of Medicine
Ramathibodi Hospital
Gastrointestinal tract whereas the remaining 3 were non-cancer
cases.
One day prior to the operation (D-1), their mean (±SEM) of
energy intake was 844 ± 65 kcal derived from 3.1% protein -, 4.7%
fat -, and 92.2% carbohydrate - calories.
On the operative day (DO)
and 1 day postoperation (D1) their mean energy intakes were 546±45
and 518±27 kcal, respectively, derived from intravenous infusion of
glucose only. During D2-7, their mean daily energy intake was
660±33 kcal derived from 3.0% protein-, 6.8% fat-, and 90.
2%
carbohydrate- calories. The following table shows that there were
drastic decreases in their serum total cholesterol (TC), low
density lipoprotein-cholesterol (LDL-C), triglyceride (TG), apoA-I,
and apo B levels at D1 due to inadequate energy and lack of protein
and fat intakes. At D7, only their serum TG and apo B levels were
significantly higher than those at D1. These findings indicate the
influences of total energy, protein and fat intakes on their serum
lipoprotein levels.
(Ramathibodi Medical Journal 1999; 22 (suppl):
133) EFFECT OF CIGARETTE SMOKING ON BLOOD LIPID
PEROXIDES AND ANTIOXIDANTS Saowanee
Kajanachumpol1, Anchlee Mahaisiriyodom2,
Pinthip Phengbhumiphanich2, Sunee
Vongboon3. 1Research Center, Faculty
of Medicine, Ramathibodi Hospital, Mahidol University,
2Department of Pathology, Priests Hospital,
3Food Microbiology, Institute of Nutrition, Mahidol
University. Key words : cigarette smoking, plasma lipid
peroxides, antioxidants
Cigarette
smoke contains vast amount of free radicals which could directly
and indirectly enhance the process of lipid peroxidation which is
detrimental to health. The aim of the present study was, therefore,
to assess the effect of cigarette smoking on the extent of lipid
peroxidation and its consequence on antioxidant status.
The study
involved determination of two plasma lipid peroxidation products,
malondialdehyde (MDA) and conjugated dienes (CD), two plasma
antioxidant vitamins (C and E) and three red blood cell (RBC)
antioxidant enzymes, superoxide dismutase (SOD), glutathione
peroxidase (GSH-Px) and catalase in 27 non- smokers and 67 smokers
(57 with plasma triglyceride ££ 200 mg/dl and 10 with plasma
triglyceride>> 200 mg/dl). The results showed that cigarette
smoking increased plasma MDA and CD, particularly in smokers with
hypertriglyceridemia, and decreased plasma
.