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Hemlock Varnish Shelf (Ganoderma tsugae) is the local variety of Reishi for eastern United States. It is common on Hemlock trees throughout the Appalachian range. Hemlock Varnish Shelf is not limited to the U.S., though, and plenty of Asian research has been conducted specifically on this species of Reishi. Variations of Ganoderma within the same species as well as the growth substrate and environmental conditions all the way through to preparation of the Ganoderma tea or extract can have a substantial effect on the medicinal value of the product. Ganoderma tsugae, also known as Hemlock varnish shelf, is a flat polypore mushroom of the genus Ganoderma.

Phylogenetic analysis of Ganodermahas begun to better differentiate between many closely related species of Ganoderma; In the case of extracting the polysaccharides in Ganoderma tsugae, a hot water extraction or tea can be very effective; however, to best extract the triterpenoids present in G. tsugae it is best to use an alcohol or alcohol/glycerin extraction method. Cap: 5-30 cm; at first irregularly knobby or elongated, but by maturity more or less fan-shaped; with a shiny, varnished surface often roughly arranged into lumpy "zones"; red to reddish brown when mature; when young often with zones of bright yellow and white toward the margin; occasionally with bluish tints. Commercially cultivated in Taiwan and exported to mainland China as a medicinal mushroom, Hemlock Reishi has traditionally been used in Chinese medicine to treat inflammatory diseases, particularly asthma and autoimmune conditions.

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Ecology: Saprobic on decaying conifer logs and stumps (especially hemlock wood); growing alone or in groups; annual; producing "a soft wet whitish or straw-colored cellulose-destroying decay of the wood" when young, and later a "network of cracks filled with white mycelium" with "numerous black dots throughout the wood" widely distributed in North America. Ganoderma lucidum is found on hardwood stumps and logs (very rarely on conifers), and has brownish flesh. Ganoderma oregonense is a conifer lover of the Pacific Northwest and New Mexico; it has larger spores and a much larger fruiting body (up to one meter across!). One study conducted in 2004 found Hemlock Varnish Shelf extract to posses liver protective properties and be anti-fibrotic. In contrast to Ganoderma lucidum, to which it is closely related and which it closely resembles, G. tsugae tends to grow on conifers, especially hemlocks.

This mushroom is closely related to Ganoderma lucidum and is virtually indistinguishable from that species. However, Ganoderma tsugae is partial to conifers--especially hemlock. A "wound area covered by SACCHACHITIN completely healed by 21 days, while that covered with cotton gauze did not."