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Microscopic Features: Spores 9-11 x 6-8; more or less elliptical, sometimes with a truncated end; usually appearing roughened even at lower magnifications. The study applied several DNA techniques and found that, while Ganoderma tsugae and Ganoderma lucidum do appear to separate with some methods, the picture is unclear enough that further study is required before reliable conclusions can be drawn. One of the most novel uses of Hemlock Varnish Shelf is as a skin substitute during wound healing. The skin substitute material, commercially sold as Sacchachitin, has been proven in numerous studies to promote and speed up skin healing. It has been observed that "rapid wound healing" takes place when covered by Sacchachitin as compared to regular gauze. Ecology: Saprobic on decaying conifer logs and stumps (especially hemlock wood); growing alone or in groups; annual; producing "a soft wet whitish or straw-colored cellulose-destroying decay of the wood" when young, and later a "network of cracks filled with white mycelium" with "numerous black dots throughout the wood" widely distributed in North America. Like Ganoderma lucidum, Ganoderma tsugae is non-poisonous but generally considered inedible, due to its solid woody nature; however, making ganoderma teas and extacts from its fruiting bodies is an excellent way make use of the medicinal compounds present in Ganoderma tsugae. A 1995 DNA study of Ganoderma (Moncalvo, Wang & Hseu) found that worldwide collections of Ganoderma tsugae may not be genetically compatible. One study conducted in 2004 found Hemlock Varnish Shelf extract to posses liver protective properties and be anti-fibrotic. Ganoderma tsugae, also known as Hemlock varnish shelf, is a flat polypore mushroom of the genus Ganoderma.

Like G. lucidum, G. tsugae is said to have medicinal properties. In contrast to Ganoderma lucidum, to which it is closely related and which it closely resembles, G. tsugae tends to grow on conifers, especially hemlocks. With Ganoderma there is still an ongoing scientific debate as to which species of Ganoderma have the most medicinal properties. Additionally, it has whitish, rather than brownish flesh. Otherwise it is recognized, like Ganoderma lucidum, by its varnished, reddish cap and stem.

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Flesh: Whitish; fairly soft when young, but soon tough. Polyporus tsugae is a former name.

Hemlock Varnish Shelf is not limited to the U.S., though, and plenty of Asian research has been conducted specifically on this species of Reishi. It also appears quite clear that Hemlock Varnish Shelf extract contains an abundance of antioxidants. A study from 1999 found Hemlock Varnish Shelf extract to possess "the strongest antioxidant activity of five species of Ganoderma tested," stronger than Vitamin E.