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Variations of Ganoderma within the same species as well as the growth substrate and environmental conditions all the way through to preparation of the Ganoderma tea or extract can have a substantial effect on the medicinal value of the product. Flesh: Whitish; fairly soft when young, but soon tough. It also appears quite clear that Hemlock Varnish Shelf extract contains an abundance of antioxidants. A study from 1999 found Hemlock Varnish Shelf extract to possess "the strongest antioxidant activity of five species of Ganoderma tested," stronger than Vitamin E. A 1995 DNA study of Ganoderma (Moncalvo, Wang & Hseu) found that worldwide collections of Ganoderma tsugae may not be genetically compatible.

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Microscopic Features: Spores 9-11 x 6-8; more or less elliptical, sometimes with a truncated end; usually appearing roughened even at lower magnifications. It also appears quite clear that Hemlock Varnish Shelf extract contains an abundance of antioxidants. A study from 1999 found Hemlock Varnish Shelf extract to possess "the strongest antioxidant activity of five species of Ganoderma tested," stronger than Vitamin E. Hemlock Varnish Shelf (Ganoderma tsugae) is the local variety of Reishi for eastern United States. It is common on Hemlock trees throughout the Appalachian range. Much of the therapeutic benefits are the same as those of the Common Reishi (Ganoderma lucidum), which is the oldest used medicinal mushroom in Traditional Chinese Medicine with a 2,000 year history. In contrast to Ganoderma lucidum, to which it is closely related and which it closely resembles, G. tsugae tends to grow on conifers, especially hemlocks.

The single study conducted on Hemlock Varnish Shelf extract to treat an autoimmune disease, conducted in 2001, concluded that it "improved the survival rate of lupus."