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Hemlock Varnish Shelf extract has also been tested for its antitumor properties with promising results. In particular lung cancer and breast cancer 816have responded favorably in scientific research. It was also shown in one study to help prevent cancer metastasis.

The single study conducted on Hemlock Varnish Shelf extract to treat an autoimmune disease, conducted in 2001, concluded that it "improved the survival rate of lupus." As with the Common Reishi, Hemlock Varnish Shelf extract appears to be immunomodulatory - meaning that it will adjust the immune system up or down depending on what is needed. It helps strengthen a weak immune system, but will calm an over-active immune system in cases of inflammation or autoimmune conditions.

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This mushroom is closely related to Ganoderma lucidum and is virtually indistinguishable from that species. However, Ganoderma tsugae is partial to conifers--especially hemlock. One study conducted in 2004 found Hemlock Varnish Shelf extract to posses liver protective properties and be anti-fibrotic. In the case of extracting the polysaccharides in Ganoderma tsugae, a hot water extraction or tea can be very effective; however, to best extract the triterpenoids present in G. tsugae it is best to use an alcohol or alcohol/glycerin extraction method. Polyporus tsugae is a former name.

Hemlock Varnish Shelf (Ganoderma tsugae) is the local variety of Reishi for eastern United States. It is common on Hemlock trees throughout the Appalachian range. Cap: 5-30 cm; at first irregularly knobby or elongated, but by maturity more or less fan-shaped; with a shiny, varnished surface often roughly arranged into lumpy "zones"; red to reddish brown when mature; when young often with zones of bright yellow and white toward the margin; occasionally with bluish tints. Commercially cultivated in Taiwan and exported to mainland China as a medicinal mushroom, Hemlock Reishi has traditionally been used in Chinese medicine to treat inflammatory diseases, particularly asthma and autoimmune conditions.