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In contrast to Ganoderma lucidum, to which it is closely related and which it closely resembles, G. tsugae tends to grow on conifers, especially hemlocks. Polyporus tsugae is a former name. A "wound area covered by SACCHACHITIN completely healed by 21 days, while that covered with cotton gauze did not." One of the most novel uses of Hemlock Varnish Shelf is as a skin substitute during wound healing. The skin substitute material, commercially sold as Sacchachitin, has been proven in numerous studies to promote and speed up skin healing. It has been observed that "rapid wound healing" takes place when covered by Sacchachitin as compared to regular gauze.

The single study conducted on Hemlock Varnish Shelf extract to treat an autoimmune disease, conducted in 2001, concluded that it "improved the survival rate of lupus." Additionally, it has whitish, rather than brownish flesh. Otherwise it is recognized, like Ganoderma lucidum, by its varnished, reddish cap and stem. Phylogenetic analysis of Ganodermahas begun to better differentiate between many closely related species of Ganoderma;

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A 1995 DNA study of Ganoderma (Moncalvo, Wang & Hseu) found that worldwide collections of Ganoderma tsugae may not be genetically compatible. Hemlock Varnish Shelf is not limited to the U.S., though, and plenty of Asian research has been conducted specifically on this species of Reishi.

Pore Surface: White, becoming dingy brownish in age; usually bruising brown; 4-6 tiny (nearly invisible to the naked eye) circular pores per mm; tubes to 2 cm deep. Flesh: Whitish; fairly soft when young, but soon tough. Hemlock Varnish Shelf (Ganoderma tsugae) is the local variety of Reishi for eastern United States. It is common on Hemlock trees throughout the Appalachian range. A 1995 DNA study of Ganoderma (Moncalvo, Wang & Hseu) found that worldwide collections of Ganoderma tsugae may not be genetically compatible. Ganoderma tsugae, also known as Hemlock varnish shelf, is a flat polypore mushroom of the genus Ganoderma.