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With Ganoderma there is still an ongoing scientific debate as to which species of Ganoderma have the most medicinal properties. In contrast to Ganoderma lucidum, to which it is closely related and which it closely resembles, G. tsugae tends to grow on conifers, especially hemlocks.

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Hemlock Varnish Shelf extract has also been tested for its antitumor properties with promising results. In particular lung cancer and breast cancer 816have responded favorably in scientific research. It was also shown in one study to help prevent cancer metastasis. One study conducted in 2004 found Hemlock Varnish Shelf extract to posses liver protective properties and be anti-fibrotic. Cap: 5-30 cm; at first irregularly knobby or elongated, but by maturity more or less fan-shaped; with a shiny, varnished surface often roughly arranged into lumpy "zones"; red to reddish brown when mature; when young often with zones of bright yellow and white toward the margin; occasionally with bluish tints. One of the most novel uses of Hemlock Varnish Shelf is as a skin substitute during wound healing. The skin substitute material, commercially sold as Sacchachitin, has been proven in numerous studies to promote and speed up skin healing. It has been observed that "rapid wound healing" takes place when covered by Sacchachitin as compared to regular gauze. The single study conducted on Hemlock Varnish Shelf extract to treat an autoimmune disease, conducted in 2001, concluded that it "improved the survival rate of lupus."

One of the most novel uses of Hemlock Varnish Shelf is as a skin substitute during wound healing. The skin substitute material, commercially sold as Sacchachitin, has been proven in numerous studies to promote and speed up skin healing. It has been observed that "rapid wound healing" takes place when covered by Sacchachitin as compared to regular gauze. A "wound area covered by SACCHACHITIN completely healed by 21 days, while that covered with cotton gauze did not."