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A "wound area covered by SACCHACHITIN completely healed by 21 days, while that covered with cotton gauze did not." A 1995 DNA study of Ganoderma (Moncalvo, Wang & Hseu) found that worldwide collections of Ganoderma tsugae may not be genetically compatible.

Ganoderma lucidum is found on hardwood stumps and logs (very rarely on conifers), and has brownish flesh. Ganoderma oregonense is a conifer lover of the Pacific Northwest and New Mexico; it has larger spores and a much larger fruiting body (up to one meter across!). As with the Common Reishi, Hemlock Varnish Shelf extract appears to be immunomodulatory - meaning that it will adjust the immune system up or down depending on what is needed. It helps strengthen a weak immune system, but will calm an over-active immune system in cases of inflammation or autoimmune conditions.

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One study conducted in 2004 found Hemlock Varnish Shelf extract to posses liver protective properties and be anti-fibrotic. Microscopic Features: Spores 9-11 x 6-8; more or less elliptical, sometimes with a truncated end; usually appearing roughened even at lower magnifications. Variations of Ganoderma within the same species as well as the growth substrate and environmental conditions all the way through to preparation of the Ganoderma tea or extract can have a substantial effect on the medicinal value of the product. In cases of asthma or lung inflammation, there have been three studies confirming the effectiveness of Hemlock Varnish Shelf. It's been found to "exert anti-inflammatory effects on airway responses" in cases of allergic asthma and broncheoalveolar inflammation. Additionally, it has whitish, rather than brownish flesh. Otherwise it is recognized, like Ganoderma lucidum, by its varnished, reddish cap and stem.

Like G. lucidum, G. tsugae is said to have medicinal properties. This mushroom is closely related to Ganoderma lucidum and is virtually indistinguishable from that species. However, Ganoderma tsugae is partial to conifers--especially hemlock. Pore Surface: White, becoming dingy brownish in age; usually bruising brown; 4-6 tiny (nearly invisible to the naked eye) circular pores per mm; tubes to 2 cm deep. Hemlock Varnish Shelf (Ganoderma tsugae) is the local variety of Reishi for eastern United States. It is common on Hemlock trees throughout the Appalachian range.