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As with the Common Reishi, Hemlock Varnish Shelf extract appears to be immunomodulatory - meaning that it will adjust the immune system up or down depending on what is needed. It helps strengthen a weak immune system, but will calm an over-active immune system in cases of inflammation or autoimmune conditions.

Like G. lucidum, G. tsugae is said to have medicinal properties. A "wound area covered by SACCHACHITIN completely healed by 21 days, while that covered with cotton gauze did not."

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Additionally, it has whitish, rather than brownish flesh. Otherwise it is recognized, like Ganoderma lucidum, by its varnished, reddish cap and stem. In cases of asthma or lung inflammation, there have been three studies confirming the effectiveness of Hemlock Varnish Shelf. It's been found to "exert anti-inflammatory effects on airway responses" in cases of allergic asthma and broncheoalveolar inflammation. Phylogenetic analysis of Ganodermahas begun to better differentiate between many closely related species of Ganoderma; One of the most novel uses of Hemlock Varnish Shelf is as a skin substitute during wound healing. The skin substitute material, commercially sold as Sacchachitin, has been proven in numerous studies to promote and speed up skin healing. It has been observed that "rapid wound healing" takes place when covered by Sacchachitin as compared to regular gauze. Ganoderma tsugae, also known as Hemlock varnish shelf, is a flat polypore mushroom of the genus Ganoderma.

One study conducted in 2004 found Hemlock Varnish Shelf extract to posses liver protective properties and be anti-fibrotic.