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Variations of ganoderma within the same species as well as the growth substrate and environmental conditions all the way through to preparation of the ganoderma tea or extract can have a substantial effect on the medicinal value of the product. With ganoderma there is still an ongoing scientific debate as to which species of ganoderma have the most medicinal properties. Commercially cultivated in Taiwan and exported to mainland China as a medicinal mushroom, Hemlock Reishi has traditionally been used in Chinese medicine to treat inflammatory diseases, particularly asthma and autoimmune conditions. Like G. lucidum, G. tsugae is said to have medicinal properties.

Hemlock Varnish Shelf (ganoderma tsugae) is the local variety of Reishi for eastern United States. It is common on Hemlock trees throughout the Appalachian range. Phylogenetic analysis of ganodermahas begun to better differentiate between many closely related species of ganoderma;

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Cap: 5-30 cm; at first irregularly knobby or elongated, but by maturity more or less fan-shaped; with a shiny, varnished surface often roughly arranged into lumpy "zones"; red to reddish brown when mature; when young often with zones of bright yellow and white toward the margin; occasionally with bluish tints. The study applied several DNA techniques and found that, while ganoderma tsugae and ganoderma lucidum do appear to separate with some methods, the picture is unclear enough that further study is required before reliable conclusions can be drawn.

In contrast to ganoderma lucidum, to which it is closely related and which it closely resembles, G. tsugae tends to grow on conifers, especially hemlocks. In contrast to ganoderma lucidum, to which it is closely related and which it closely resembles, G. tsugae tends to grow on conifers, especially hemlocks. Hemlock Varnish Shelf is not limited to the U.S., though, and plenty of Asian research has been conducted specifically on this species of Reishi.