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In the case of extracting the polysaccharides in ganoderma tsugae, a hot water extraction or tea can be very effective; however, to best extract the triterpenoids present in G. tsugae it is best to use an alcohol or alcohol/glycerin extraction method. ganoderma lucidum is found on hardwood stumps and logs (very rarely on conifers), and has brownish flesh. ganoderma oregonense is a conifer lover of the Pacific Northwest and New Mexico; it has larger spores and a much larger fruiting body (up to one meter across!). Variations of ganoderma within the same species as well as the growth substrate and environmental conditions all the way through to preparation of the ganoderma tea or extract can have a substantial effect on the medicinal value of the product. It also appears quite clear that Hemlock Varnish Shelf extract contains an abundance of antioxidants. A study from 1999 found Hemlock Varnish Shelf extract to possess "the strongest antioxidant activity of five species of ganoderma tested," stronger than Vitamin E.

Spore Print: Brown. Hemlock Varnish Shelf (ganoderma tsugae) is the local variety of Reishi for eastern United States. It is common on Hemlock trees throughout the Appalachian range.

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In contrast to ganoderma lucidum, to which it is closely related and which it closely resembles, G. tsugae tends to grow on conifers, especially hemlocks. Stem: Sometimes absent, but more commonly present; 3-14 cm long; up to 3 cm thick; twisted; equal or irregular; varnished and colored like the cap; often distinctively angled away from one side of the cap. Like G. lucidum, G. tsugae is said to have medicinal properties.

Variations of ganoderma within the same species as well as the growth substrate and environmental conditions all the way through to preparation of the ganoderma tea or extract can have a substantial effect on the medicinal value of the product. The study applied several DNA techniques and found that, while ganoderma tsugae and ganoderma lucidum do appear to separate with some methods, the picture is unclear enough that further study is required before reliable conclusions can be drawn. ganoderma lucidum is found on hardwood stumps and logs (very rarely on conifers), and has brownish flesh. ganoderma oregonense is a conifer lover of the Pacific Northwest and New Mexico; it has larger spores and a much larger fruiting body (up to one meter across!).