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Hemlock Varnish Shelf extract has also been tested for its antitumor properties with promising results. In particular lung cancer and breast cancer 816have responded favorably in scientific research. It was also shown in one study to help prevent cancer metastasis. Much of the therapeutic benefits are the same as those of the Common Reishi (ganoderma lucidum), which is the oldest used medicinal mushroom in Traditional Chinese Medicine with a 2,000 year history. This mushroom is closely related to ganoderma lucidum and is virtually indistinguishable from that species. However, ganoderma tsugae is partial to conifers--especially hemlock. Commercially cultivated in Taiwan and exported to mainland China as a medicinal mushroom, Hemlock Reishi has traditionally been used in Chinese medicine to treat inflammatory diseases, particularly asthma and autoimmune conditions.

ganoderma lucidum is found on hardwood stumps and logs (very rarely on conifers), and has brownish flesh. ganoderma oregonense is a conifer lover of the Pacific Northwest and New Mexico; it has larger spores and a much larger fruiting body (up to one meter across!). As with the Common Reishi, Hemlock Varnish Shelf extract appears to be immunomodulatory - meaning that it will adjust the immune system up or down depending on what is needed. It helps strengthen a weak immune system, but will calm an over-active immune system in cases of inflammation or autoimmune conditions. A 1995 DNA study of ganoderma (Moncalvo, Wang & Hseu) found that worldwide collections of ganoderma tsugae may not be genetically compatible.

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Spore Print: Brown. Additionally, it has whitish, rather than brownish flesh. Otherwise it is recognized, like ganoderma lucidum, by its varnished, reddish cap and stem. Like ganoderma lucidum, ganoderma tsugae is non-poisonous but generally considered inedible, due to its solid woody nature; however, making ganoderma teas and extacts from its fruiting bodies is an excellent way make use of the medicinal compounds present in ganoderma tsugae.

The single study conducted on Hemlock Varnish Shelf extract to treat an autoimmune disease, conducted in 2001, concluded that it "improved the survival rate of lupus." Polyporus tsugae is a former name. One of the most novel uses of Hemlock Varnish Shelf is as a skin substitute during wound healing. The skin substitute material, commercially sold as Sacchachitin, has been proven in numerous studies to promote and speed up skin healing. It has been observed that "rapid wound healing" takes place when covered by Sacchachitin as compared to regular gauze.