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Commercially cultivated in Taiwan and exported to mainland China as a medicinal mushroom, Hemlock Reishi has traditionally been used in Chinese medicine to treat inflammatory diseases, particularly asthma and autoimmune conditions. The single study conducted on Hemlock Varnish Shelf extract to treat an autoimmune disease, conducted in 2001, concluded that it "improved the survival rate of lupus."

Ecology: Saprobic on decaying conifer logs and stumps (especially hemlock wood); growing alone or in groups; annual; producing "a soft wet whitish or straw-colored cellulose-destroying decay of the wood" when young, and later a "network of cracks filled with white mycelium" with "numerous black dots throughout the wood" widely distributed in North America. Hemlock Varnish Shelf extract has also been tested for its antitumor properties with promising results. In particular lung cancer and breast cancer 816have responded favorably in scientific research. It was also shown in one study to help prevent cancer metastasis. Spore Print: Brown.

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It also appears quite clear that Hemlock Varnish Shelf extract contains an abundance of antioxidants. A study from 1999 found Hemlock Varnish Shelf extract to possess "the strongest antioxidant activity of five species of Ganoderma tested," stronger than Vitamin E. A 1995 DNA study of Ganoderma (Moncalvo, Wang & Hseu) found that worldwide collections of Ganoderma tsugae may not be genetically compatible. Stem: Sometimes absent, but more commonly present; 3-14 cm long; up to 3 cm thick; twisted; equal or irregular; varnished and colored like the cap; often distinctively angled away from one side of the cap. A 1995 DNA study of Ganoderma (Moncalvo, Wang & Hseu) found that worldwide collections of Ganoderma tsugae may not be genetically compatible.

In the case of extracting the polysaccharides in Ganoderma tsugae, a hot water extraction or tea can be very effective; however, to best extract the triterpenoids present in G. tsugae it is best to use an alcohol or alcohol/glycerin extraction method.