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With Ganoderma there is still an ongoing scientific debate as to which species of Ganoderma have the most medicinal properties. With Ganoderma there is still an ongoing scientific debate as to which species of Ganoderma have the most medicinal properties.

The single study conducted on Hemlock Varnish Shelf extract to treat an autoimmune disease, conducted in 2001, concluded that it "improved the survival rate of lupus." Like G. lucidum, G. tsugae is said to have medicinal properties. It also appears quite clear that Hemlock Varnish Shelf extract contains an abundance of antioxidants. A study from 1999 found Hemlock Varnish Shelf extract to possess "the strongest antioxidant activity of five species of Ganoderma tested," stronger than Vitamin E.

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With Ganoderma there is still an ongoing scientific debate as to which species of Ganoderma have the most medicinal properties. Additionally, it has whitish, rather than brownish flesh. Otherwise it is recognized, like Ganoderma lucidum, by its varnished, reddish cap and stem. Stem: Sometimes absent, but more commonly present; 3-14 cm long; up to 3 cm thick; twisted; equal or irregular; varnished and colored like the cap; often distinctively angled away from one side of the cap.

Microscopic Features: Spores 9-11 x 6-8; more or less elliptical, sometimes with a truncated end; usually appearing roughened even at lower magnifications. In contrast to Ganoderma lucidum, to which it is closely related and which it closely resembles, G. tsugae tends to grow on conifers, especially hemlocks. As with the Common Reishi, Hemlock Varnish Shelf extract appears to be immunomodulatory - meaning that it will adjust the immune system up or down depending on what is needed. It helps strengthen a weak immune system, but will calm an over-active immune system in cases of inflammation or autoimmune conditions.