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The single study conducted on Hemlock Varnish Shelf extract to treat an autoimmune disease, conducted in 2001, concluded that it "improved the survival rate of lupus." Ganoderma lucidum is found on hardwood stumps and logs (very rarely on conifers), and has brownish flesh. Ganoderma oregonense is a conifer lover of the Pacific Northwest and New Mexico; it has larger spores and a much larger fruiting body (up to one meter across!).

In cases of asthma or lung inflammation, there have been three studies confirming the effectiveness of Hemlock Varnish Shelf. It's been found to "exert anti-inflammatory effects on airway responses" in cases of allergic asthma and broncheoalveolar inflammation. In the case of extracting the polysaccharides in Ganoderma tsugae, a hot water extraction or tea can be very effective; however, to best extract the triterpenoids present in G. tsugae it is best to use an alcohol or alcohol/glycerin extraction method. Ganoderma tsugae, also known as Hemlock varnish shelf, is a flat polypore mushroom of the genus Ganoderma. Additionally, it has whitish, rather than brownish flesh. Otherwise it is recognized, like Ganoderma lucidum, by its varnished, reddish cap and stem. Ganoderma tsugae, also known as Hemlock varnish shelf, is a flat polypore mushroom of the genus Ganoderma.

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Like Ganoderma lucidum, Ganoderma tsugae is non-poisonous but generally considered inedible, due to its solid woody nature; however, making ganoderma teas and extacts from its fruiting bodies is an excellent way make use of the medicinal compounds present in Ganoderma tsugae.

Commercially cultivated in Taiwan and exported to mainland China as a medicinal mushroom, Hemlock Reishi has traditionally been used in Chinese medicine to treat inflammatory diseases, particularly asthma and autoimmune conditions. In cases of asthma or lung inflammation, there have been three studies confirming the effectiveness of Hemlock Varnish Shelf. It's been found to "exert anti-inflammatory effects on airway responses" in cases of allergic asthma and broncheoalveolar inflammation. In cases of asthma or lung inflammation, there have been three studies confirming the effectiveness of Hemlock Varnish Shelf. It's been found to "exert anti-inflammatory effects on airway responses" in cases of allergic asthma and broncheoalveolar inflammation. Variations of Ganoderma within the same species as well as the growth substrate and environmental conditions all the way through to preparation of the Ganoderma tea or extract can have a substantial effect on the medicinal value of the product. Like Ganoderma lucidum, Ganoderma tsugae is non-poisonous but generally considered inedible, due to its solid woody nature; however, making ganoderma teas and extacts from its fruiting bodies is an excellent way make use of the medicinal compounds present in Ganoderma tsugae.