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The single study conducted on Hemlock Varnish Shelf extract to treat an autoimmune disease, conducted in 2001, concluded that it "improved the survival rate of lupus." Variations of Ganoderma within the same species as well as the growth substrate and environmental conditions all the way through to preparation of the Ganoderma tea or extract can have a substantial effect on the medicinal value of the product. Stem: Sometimes absent, but more commonly present; 3-14 cm long; up to 3 cm thick; twisted; equal or irregular; varnished and colored like the cap; often distinctively angled away from one side of the cap. The single study conducted on Hemlock Varnish Shelf extract to treat an autoimmune disease, conducted in 2001, concluded that it "improved the survival rate of lupus."

Commercially cultivated in Taiwan and exported to mainland China as a medicinal mushroom, Hemlock Reishi has traditionally been used in Chinese medicine to treat inflammatory diseases, particularly asthma and autoimmune conditions. A "wound area covered by SACCHACHITIN completely healed by 21 days, while that covered with cotton gauze did not." Ecology: Saprobic on decaying conifer logs and stumps (especially hemlock wood); growing alone or in groups; annual; producing "a soft wet whitish or straw-colored cellulose-destroying decay of the wood" when young, and later a "network of cracks filled with white mycelium" with "numerous black dots throughout the wood" widely distributed in North America. In the case of extracting the polysaccharides in Ganoderma tsugae, a hot water extraction or tea can be very effective; however, to best extract the triterpenoids present in G. tsugae it is best to use an alcohol or alcohol/glycerin extraction method. One of the most novel uses of Hemlock Varnish Shelf is as a skin substitute during wound healing. The skin substitute material, commercially sold as Sacchachitin, has been proven in numerous studies to promote and speed up skin healing. It has been observed that "rapid wound healing" takes place when covered by Sacchachitin as compared to regular gauze. Hemlock Varnish Shelf extract has also been tested for its antitumor properties with promising results. In particular lung cancer and breast cancer 816have responded favorably in scientific research. It was also shown in one study to help prevent cancer metastasis. In the case of extracting the polysaccharides in Ganoderma tsugae, a hot water extraction or tea can be very effective; however, to best extract the triterpenoids present in G. tsugae it is best to use an alcohol or alcohol/glycerin extraction method. Spore Print: Brown.

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Flesh: Whitish; fairly soft when young, but soon tough. Ganoderma lucidum is found on hardwood stumps and logs (very rarely on conifers), and has brownish flesh. Ganoderma oregonense is a conifer lover of the Pacific Northwest and New Mexico; it has larger spores and a much larger fruiting body (up to one meter across!). Ganoderma lucidum is found on hardwood stumps and logs (very rarely on conifers), and has brownish flesh. Ganoderma oregonense is a conifer lover of the Pacific Northwest and New Mexico; it has larger spores and a much larger fruiting body (up to one meter across!).

Additionally, it has whitish, rather than brownish flesh. Otherwise it is recognized, like Ganoderma lucidum, by its varnished, reddish cap and stem. Pore Surface: White, becoming dingy brownish in age; usually bruising brown; 4-6 tiny (nearly invisible to the naked eye) circular pores per mm; tubes to 2 cm deep. Commercially cultivated in Taiwan and exported to mainland China as a medicinal mushroom, Hemlock Reishi has traditionally been used in Chinese medicine to treat inflammatory diseases, particularly asthma and autoimmune conditions.