Ganoderma
The Effects Of Ganoderma Lucidum Extracts On N18 Neuroblastoma Cells
Mahidol University Annual Research Abstracts 250 Faculty of Science It should be note that oxidative stress was detected in both thalassemic LDL and HDL.
We then postulated that, under oxidative insults, the physical alterations should be occurred specifically for some lipids and proteins. Modified HDL may take an important role on pathology of thalassemia. (Supported by a research grant from Faculty of Science, Mahidol University) THE EFFECTS OF GANODERMA LUCIDUM EXTRACTS ON N18 NEUROBLASTOMA CELLS. (NO.
679) Porntip Supavilai, Duangchai Limsakul, and Porntipa Picha Department of Pharmacology, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand Key words: Ganoderma lucidum / antioxidant enzymes / N18 neuroblastoma cells / cytotoxic effect GANODERMA LUCIDUM (GL) is an herbal medicine with antitumor activity capable of suppressing the growth of various tumors in vivo. The exact mechanism of GL against tumor cells is not clearly understood. Our previous study indicated that GL extracts exhibited no cytotoxic effect in P388 mouse leukemic cells (P388 cells) but they could inhibit the growth of P388 cells. The growth inhibition of P388 cells was not correlated with GSH peroxidase and catalase enzymes.
This inhibition may result from the increased SOD activity. The present study aimed to evaluate the direct cytotoxic effect of crude polysaccharide fractions (FO and FA) of GL extracts from both Thai and Japanese strains in N18 neuroblastoma cells. In addition, the activity of various antioxidant enzymes (superoxide dismutase (SOD), glutathione (GSH) peroxidase, and catalase) were measured in N18 neuroblastoma.both in the absence and in the presence of GL extracts.
AN EFFICIENT INVERSION : TWO-DIMEN-SIONAL MAGNETOTELLURIC DATA (NO. 680) Weerachai Siripunvaraporn Department of Physics, Faculty of Science, Mahidol University Key words : Inversion, Magnetotelluric The Magnetotelluric (MT) has found increasing use in both geophysical exploration application and in fundamental studies of large-scale tectonics. Initial applications were based on local 1-D interpretations. It is now clear that 2-D or even 3-D interpretation is essential for most real MT data sets, which leads to a high demand on fast, stable and reliable 2-D or 3-D inversion methods.
Generally, most reliable and efficient 2-D inversion methods require extensive computational time and memory. To overcome these difficulties, we present a new and much more efficient inversion algorithm, the reduced basis Occams inversion (REBOCC). The algorithm is based on the transformation of the linearized inverse problem from the model space into the data space, which can result in significant computational saving. More importantly the data space formulation suggests a simple approximate method for constructing the inverse solution.
Since MT data are smooth and redundant, the solution can be constructed from subsets of the data, without significant loss of detail, and still fit all data adequately. This leads to a dramatic reduction of computational costs. Numerical experiments on synthetic and real data sets with REB